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Tohoku University Technology: Compounds that suppress ferroptosis: T20-485

Vitamin K and its derivative

Ferroptosis is a form of regulated cell death associated with neurodegenerative diseases (e.g. Alzheimer's disease) and organ damage and is attracting attention as a therapeutic target. In this study, we found that vitamin K (especially the reduced form), a functional food ingredient, has a potent preventing effect on ferroptosis. Although a higher intake of vitamin K than those from the diet would be required to exert the anti-ferroptotic effect, vitamin K can be safely used even at high doses due to the no harmful effect reported. Thus, high-dose vitamin K supplementation is expected to be commercialized as a dietary supplement, functional food, and medicine.

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